tenofovir-alafenamide-hemifumarate

Description:Tenofovir Alafenamide hemifumarate (formerly also known as TAF and GS-7340) is anovel prodrug of tenofovir, which is a potent reverse transcriptaseinhibitor nucleotide reverse transcriptase inhibitor (NRTIs), it isused for the treatment of HIV and Hepatitis B. By blocking reversetranscriptase, Tenofovir Alafenamide prevent HIV from multiplying andcan reduce the amount of HIV in the body. Tenofovir alafenamide is aprodrug that it is inactive in the parent form, and has to be convertedto tenofovir diphosphate (TFV-DP) in vivo.

References: Nucleosides Nucleotides Nucleic Acids. 2001; 20:1085-90; Antimicrob Agents Chemother. 2005; 49:1898-906.

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