tamoxifen

ArtNr	V1742-25g
Hersteller	InvivoChem LLC
CAS-Nr.	10540-29-1
Menge	25g
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Lieferbar
Description	InvivoChem Cat #:V1742CAS #:10540-29-1Purity >=98% Description: Tamoxifen, also known as ICI 46474, is a potent and selective estrogen receptor modulator (SERM) in breast tissue by competitive inhibition of estrogen binding. In other tissues such as the endometrium, it acts as an agonist, and thus may be characterized as a selective estrogen-receptor modulator. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Tamoxifen, also known as ICI 46474, is a potent and selective estrogen receptor modulator (SERM) in breast tissue by competitive inhibition of estrogen binding. In other tissues such as the endometrium, it acts as an agonist, and thus may be characterized as a selective estrogen-receptor modulator. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. References: Pharmacol Ther. 1984; 25(2):127-205; N Engl J Med. 1998 Nov 26; 339(22):1609-18. Related CAS #: 54965-24-1 (citrate) 10540-29-1 (free base)
Molecular Weight (MW)	371.51
Formula	C26H29NO
CAS No.	10540-29-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 74 mg/mL (199.2 mM)
	Water: < 1 mg/mL
	Ethanol: 74 mg/mL (199.2 mM)
Solubility (In vivo)	Chemical Name: 2-[4-[(1Z)-1, 2-diphenyl-1-buten-1-yl]phenoxy]-N, N-dimethyl-ethanamine InChi Key: NKANXQFJJICGDU-QPLCGJKRSA-N InChi Code: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H, 4, 19-20H2, 1-3H3/b26-25- SMILES Code: CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3v
Synonyms	ICI 46474; ICI-46474; ICI46474; NSC 180973, tamoxifen, tamoxifeni citras, Nolvadex, Novaldex

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