Cyproterone Acetate

Description: Cyproterone acetate, an analog of 17-hydroxyprogesterone, is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. It works by blocking androgen receptors which prevents androgens from binding to them and suppresses luteinizing hormone, which in turn reduces testosterone levels. It is primarily used to treat prostate cancer, benign prostatic hyperplasia, priapism, hypersexuality and other conditions.

References: Toxicol Sci. 2005 Jan; 83(1):136-48; Mol Cell Endocrinol. 2010 Oct 26; 328(1-2):16-21.

Synonyms: Cyprone, Cyprohexal, Ciproterona, Cyproteronum, Androcur, Cyprostat, Cyproteron, Procur, Neoproxil, Siterone.

Chemical Name: (2aR, 3aS, 3bS, 3cS, 5aS, 6R, 8aS, 8bR)-6-acetyl-10-chloro-3b, 5a-dimethyl-2-oxo-2, 2a, 3, 3a, 3b, 3c, 4, 5, 5a, 6, 7, 8, 8a, 8b-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-6-yl acetate

InChi Key: UWFYSQMTEOIJJG-FDTZYFLXSA-N

InChi Code: InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19, 4)17(14)5-7-22(16, 24)3/h10-11, 14-18H, 5-9H2, 1-4H3/t14-, 15+, 16-, 17-, 18-, 22-, 23-, 24-/m0/s1

SMILES Code: CC(O[C]1(C(C)=O)CC[C]2([H])[C]1(C)CC[C]3([H])[C]4(C)[C](C5)([H])[C]5([H])C(C=C4C(Cl)=C[C]23[H])=O)=O