Entecavir Hydrate (BMS200475)

Description: Entecavir (also known as SQ 34676 and BMS 200475), anti-hepatitis B virus (HBV) agent, is a novel deoxyguanine nucleoside analogue and a reverse transcriptase inhibitor. Entecavir is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cells. It is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Entecavir is a highly potent inhibitor of wild-type HBV Pol and is 100- to 300-fold more potent than lamivudine-triphosphate against 3TC-resistant HBV Pol. Entecavir inhibits the replication of 3TC-resistant HBV, but 20- to 30-fold higher concentrations are required.

References: Antimicrob Agents Chemother. 2002 Aug; 46(8):2525-32; Antimicrob Agents Chemother. 2003 Aug; 47(8):2624-35.

Related CAS#: 142217-69-4 (free); 911138-73-3 (maleate); 209216-23-9 (hydrate)