dibutyryl-camp-bucladesine

Description: Bucladesine sodium (also known as Dibutyryl-cAMP sodium), the sodium salt of Bucladesine, is a cell-permeable PKA activator and a cAMP analog that mimics the action of endogenous cAMP. It is a cyclic nucleotide derivative (structurally similar to cAMP) and is also a phosphodiesterase inhibitor. Dibutyryl-cAMP preferentially activates cAMP-dependent protein kinase. The products releaes butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.

References: Exp Neurol. 2001 Jan; 167(1):59-64.

Related CAS#: 362-74-3 (Bucladesine); 938448-87-4 (Bucladesine calcium salt); 16980-89-5 (sodium salt)

dbcAMP; Dibutyryl-cAMP sodium salt; DC2797; DC-2797; DC 2797; Sodium dibutyryl cAMP; Bucladesine sodium; DbcAMP sodium; Actosin; Sodium Dibutyryl cAMP; Cyclic dibutyryl-AMP sodium salt

Chemical Name: sodium (4aR, 6R, 7R, 7aR)-6-(6-butyramido-9H-purin-9-yl)-7-(butyryloxy)tetrahydro-4H-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-olate 2-oxide

SMILES Code: O=P1(OC[CH]2O[CH]([CH]([CH]2O1)OC(CCC)=O)N3C4=NC=NC(NC(CCC)=O)=C4N=C3)[O-].[Na+]