Flufenamic acid (CI-440; CN-27554)

Description: Flufenamic Acid (CI-440; CN-27554) is an anti-inflammatory agent of the NSAIDs (non-steroidal anti-inflammatory agent) class. It inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. . Flufenamic acids reversibly inhibits ICl(Ca) in Xenopus oocytes with IC50 of 28 mM, elicit in response to depolarizing voltage steps, in a dose-dependent manner, with no effect on the shape of the current-voltage curve. Flufenamic acids blocks Ca2(+)-activated non-selective cation channels in inside-out patches from the basolateral membrane of rat exocrine pancreatic cells with IC50 of 10 uM.

References: Mol Pharmacol. 1990 May; 37(5):720-4; FEBS Lett. 1990 Jul 30; 268(1):79-82; Bioorg Med Chem. 1999 Jul; 7(7):1339-47.