YKL-05-099

InvivoChem Cat #:V2134CAS #:1936529-65-5 Purity >=98%

Description: YKL-05-099 is a novel, potent and selective inhibitor of salt-inducible kinase (SIK). YKL-05-099 acts by binding to SIK1 and SIK3 with IC50s of ca.10 and ca.30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM).

References: ACS Chem Biol. 2016 Aug 19; 11(8):2105-11.

-20C for 3 years in powder form

Synonym: YKL-05-099; YKL 05 099; YKL05099;
Chemical Name: 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3, 4-dihydropyrimido[4, 5-d]pyrimidin-2(1H)-one
InChi Key: VQINULODWGEVBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C32H34ClN7O3/c1-20-6-5-7-25(33)29(20)39-19-23-17-35-31(37-30(23)40(32(39)41)28-11-9-24(42-3)18-34-28)36-26-10-8-22(16-27(26)43-4)21-12-14-38(2)15-13-21/h5-11, 16-18, 21H, 12-15, 19H2, 1-4H3, (H, 35, 36, 37)
SMILES Code: O=C1N(C2=NC=C(OC)C=C2)C3=NC(NC4=CC=C(C5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6Cl