Danofloxacin Mesylate (CP 76136-27)

Description: Danofloxacin Mesylate (also known as CP-76136-27) is a fluoroquinolone class of antibiotic for veterinary use, with MIC90 of 0.28 uM. Danofloxacin Mesylate acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 ug/ml. Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay.

References: J Vet Pharmacol Ther. 1991 Dec; 14(4):400-10; J Med Chem. 1992 Feb 21; 35(4):611-20.

Related CAS #: 112398-08-0 (free base) 119478-55-6 (mesylate)

Synonym: CP 76, 136-27; CP-76, 136-27; Danofloxacin monomethanesulfonate.

Chemical Name: 1-Cyclopropyl-6-fluoro-1, 4-dihydro-7-((1S, 4S)-5-methyl-2, 5-diazabicyclo(2.2.1)hept-2-yl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate

InChi Key: APFDJSVKQNSTKF-FXMYHANSSA-N

InChi Code: InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10; 1-5(2, 3)4/h5-6, 9-12H, 2-4, 7-8H2, 1H3, (H, 25, 26); 1H3, (H, 2, 3, 4)/t11-, 12-; /m0./s1

SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C](C5)([H])CN(C)[C]5([H])C4)=C3)C1=O)O.CS(=O)(O)=O