B02

Description: B02 (also called RAD51-IN-02)is a potent and specific inhibitor of human RAD51 with an IC50 of 27.4 uM. RAD51, a key homologous recombination protein, promotes the search for homology and DNA strand exchange between homologous DNA molecules. RAD51 is overexpressed in a variety of cancer cells. Downregulation of RAD51 by siRNA increases radio- or chemo-sensitivity of cancer cells. B02 blocks HR repair in human embryonic kidney (HEK) and breast cancer cells and increases their sensitivity to a wide range of DNA damaging agents. Also, B02 enhances DNA damage and apoptosis induced by decitabine in MM cells. B02 shows high specificity for RAD51 and does not significantly inhibit RAD54 in the range of concentrations from 0 to 200 uM.

References: Front Oncol. 2014; 4:289; ACS Chem Biol. 2011; 6(6):628-35; PLoS One. 2014; 9(6):e100993.