tianeptine

Description: Tianeptine (Tatinol, Tianeurax and Salymbra) is a potent and selective serotonin reuptake enhancer (SSRE) used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.

References: Neuropharmacology. 2006 Jun; 50(7):824-33; Stress. 2006 Mar; 9(1):29-40.

Related CAS #: 72797-41-2 (free acid); 30123-17-2 (sodium)