Norfloxacin hydrochloride (MK-0366)

Description: Norfloxacin hydrochloride (MK-0366) is a broad-spectrum and synthetic chemotherapeutic antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase. Norfloxacin is used to treat common as well as complicated urinary tract infections. It is a first generation synthetic fluoroquinolone and is approved for the treatment of urinary tract infections, prostatitis, and sexually transmitted diseases, although it is no longer used for the latter due to bacterial resistance.

References: Eur Urol. 1990; 17 Suppl 1:13-8; Clin Infect Dis. 2007 Apr 1; 44(7):977-80

Related CAS: 85181-48-2 (Norfloxacin glutamate); 68077-27-0 (Norfloxacin hydrochloride); 70458-96-7 (free)