UNC0321

InvivoChem Cat #:V3453CAS #:1238673-32-9Purity >=98%

Description: UNC0321 is a novel, potent and selective G9a histone methyltransferase inhibitor with Ki of 63 pM, UNC0321 was discovered by optimizing the 7-dimethylaminopropoxy side chain on the basis of the structural insights revealed by UNC0224-G9a cocrystal structure. UNC0321 is the first G9a inhibitor with picomolar potency.

References: J Med Chem. 2011 Sep 8; 54(17):6139-50; J Med Chem. 2010 Aug 12; 53(15):5844-57. d

-20C for 3 years in powder form

Synonym: UNC0321, UNC-0321, UNC 0321, CHEMBL1214066, CHEBI:785916, NCGC0018778901, KB81388
Chemical Name: 7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1, 4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
InChi Key: AULLUGALUBVBDD-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H45N7O3/c1-31(2)15-16-36-17-18-37-25-20-23-22(19-24(25)35-5)26(28-21-7-11-33(4)12-8-21)30-27(29-23)34-10-6-9-32(3)13-14-34/h19-21H, 6-18H2, 1-5H3, (H, 28, 29, 30)
SMILES Code: CN1CCC(NC2=C3C=C(OC)C(OCCOCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1