Lomitapide mesylate

InvivoChem Cat #:V3505CAS #:202914-84-9 (mesylate); 182431-12-5 (free base)Purity >=98%

Description: Lomitapide (also known as AEGR-733 and BMS-201038) is a novel and potent inhibitor of microsomal triglyceride-transfer protein (MTP) with IC50 of 8 nM in vitro. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH.

References: Am J Health Syst Pharm. 2014 Jun 15; 71(12):1001-8.

-20C for 3 years in powder form

Synonym: BMS 201038; BMS-201038; BMS201038; AEGR 733; AEGR733; AEGR-733; BMS 201038-01. Lomitapide mesylate. Brand name: Juxtapid; Lojuxta.
Chemical Name: N-(2, 2, 2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1, 1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate
InChi Key: QKVKOFVWUHNEBX-UHFFFAOYSA-N
InChi Code: InChI=1S/C39H37F6N3O2.CH4O3S/c40-38(41, 42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43, 44)45; 1-5(2, 3)4/h1-6, 9-18, 28H, 7-8, 19-25H2, (H, 46, 50)(H, 47, 49); 1H3, (H, 2, 3, 4)
SMILES Code: O=C(C1(CCCCN2CCC(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)CC2)C5=C(C6=C1C=CC=C6)C=CC=C5)NCC(F)(F)F.OS(=O)(C)=O