Lanopepden

InvivoChem Cat #:V3525CAS #:1152107-25-9Purity >=98%

Description: Lanopepden (formerly known as GSK 1322322 and GSK-322) is a novel, potent and selective peptide deformylase inhibitor with activity against Staphylococcus aureus strains with MICs of 1 and 1 mg/L for ATCC 29213 and ATCC 25923 strain, respectively. It has good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. Lanopepden had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a >= 3-log(10) decrease in the number of CFU/ml at 4x MIC within 24 h in 29 of the 33 strains tested. Lanopepden represents a valuable alternative therapy for the treatment of infectious diseases caused by drug-resistant pathogens.

References: Antimicrob Agents Chemother. 2015 Sep; 59(9):5747-60.

Related CAS#:1441390-17-5 (mesylate)

-20C for 3 years in powder form

Synonym: GSK-322; GSK322; GSK 322; GSK-1322322; GSK1322322; GSK 1322322; GSK-1322322B; GSK-1322322J; GSK 1322322B
Chemical Name: N-[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro- 6-[(9aS)-hexahydropyrazino[2, 1-c][1, 4]oxazin-8(1H)-yl]- 2-methylpyrimidin-4-yl}hydrazin-1-yl)-3-oxopropyl]- N-hydroxyformamide
InChi Key: SWHNZGMQMGFQGW-MSOLQXFVSA-N
InChi Code: InChI=1S/C22H34FN7O4/c1-15-24-20(19(23)21(25-15)29-7-6-28-8-9-34-13-18(28)12-29)26-27-22(32)17(11-30(33)14-31)10-16-4-2-3-5-16/h14, 16-18, 33H, 2-13H2, 1H3, (H, 27, 32)(H, 24, 25, 26)/t17-, 18+/m1/s1
SMILES Code: O=CN(C[CH](CC1CCCC1)C(NNC2=NC(C)=NC(N3C[C]4([H])COCCN4CC3)=C2F)=O)O