fiboflapon-sodium

InvivoChem Cat #:V3624CAS #:1196070-26-4Purity >=98%

Description: Fiboflapon sodium (also known as AM-803 and GSK2190915 sodium) is a novel, orally bioavailable and potent FLAP (5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM. Fiboflapon attenuated the early (0-2 h) and late (4-10 h) asthmatic responses to inhaled allergen compared with placebo. GSK2190915 shows potential as a treatment for patients with asthma. Efficacy was demonstrated for GSK2190915 30 mg compared with placebo in day-time symptom scores and day-time SABA use.

References: J Med Chem. 2011 Dec 8; 54(23):8013-29.; Eur J Pharmacol. 2010 Aug 25; 640(1-3):211-8.

Related CAS#:936350-00-4 (free acid)

-20C for 3 years in powder form

Synonym: AM-803; GSK-2190915; AM803; GSK2190915; AM 803; GSK 2190915; 2190915; GSK2190915A
Chemical Name: sodium 3-(3-(tert-butylthio)-1-(4-(6-ethoxypyridin-3-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2, 2-dimethylpropanoate
InChi Key: NOJNFULGOQGBKB-UHFFFAOYSA-M
InChi Code: InChI=1S/C38H43N3O4S.Na/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3, 4)5)33(41)20-38(6, 7)36(42)43; /h9-19, 21-22H, 8, 20, 23-24H2, 1-7H3, (H, 42, 43); /q; +1/p-1
SMILES Code: O=C([O-])C(C)(C)CC(N1CC2=CC=C(C3=CC=C(OCC)N=C3)C=C2)=C(SC(C)(C)C)C4=C1C=CC(OCC5=NC=C(C)C=C5)=C4.[Na+]