MCC950

Description: MCC950 (also known as MCC-950, CP-456773 or CRID3) is a potent, selective, small-molecule inhibitor of NLRP3 that has the potential for the treatment of inflammatory diseases and diabetic encephalopathy (DEP). MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1beta (IL-1beta) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Furthermore, MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle-Wells syndrome. MCC950 is thus a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease. In addition, inhibiting the NLRP3 Inflammasome sctivation with MCC950 may ameliorate diabetic encephalopathy (DEP) in db/db mice.

References: Nat Med. 2015 Mar; 21(3):248-55; Molecules. 2018 Feb 27; 23(3). pii: E522.

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