blu-782

InvivoChem Cat #:V4129CAS #:2141955-96-4Purity >=98%

Description: BLU-782 has been discontinued. BLU-782 (also known as ALK2-IN-1) is a novel, potent, selective, and oral bioactive inhibitor of ALK2 (Activin receptor-like kinase) mutant R206H with binding IC50 of< 10 nM, it was designed to selectively target the mutant FOP receptor (ACVR1/ALK2) which is the underlying cause of FOP. In FOP mice, BLU-782 prevented the formation of injury-induced heterotopic ossification (HO) and tissue swelling (edema). BLU-782 also prevented the formation of HO following surgery in FOP mice. BLU-782 is under development for the treatment of fibrodysplasia ossificans progressiva.

Description:

References: PCT Int. Appl. (2017), WO 2017181117 A1 20171019.

References:

-20C for 3 years in powder form

Synonym: BLU-782; BLU 782; BLU782; ALK2-IN-1; ALK2-IN 1; ALK2-IN1
IUPAC/Chemical Name: 1-Piperazinecarboxylic acid, 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1, 2-b]pyridazin-4-yl]-, (3R)-tetrahydro-3-furanyl ester
InChi Key: SWVYYNLRVIYURK-AREMUKBSSA-N
InChi Code: InChI=1S/C31H42N6O4/c1-4-40-31(9-12-34(13-10-31)23(2)3)25-5-6-27(32-20-25)24-19-29-28(7-11-33-37(29)21-24)35-14-16-36(17-15-35)30(38)41-26-8-18-39-22-26/h5-7, 11, 19-21, 23, 26H, 4, 8-10, 12-18, 22H2, 1-3H3/t26-/m1/s1
SMILES Code: O=C(N1CCN(C2=CC=NN3C2=CC(C4=NC=C(C5(OCC)CCN(C(C)C)CC5)C=C4)=C3)CC1)O[CH]6COCC6