pf-06465469

InvivoChem Cat #:V4445CAS #:1407966-77-1 Purity >=98%

Description: PF-06465469 is a novel, potent and covalent inhibitor of ITK (IL-2 inducible T-cell kinase) with an IC50 of 2?nM. ITK is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells.

References: Sci Rep. 2018 Sep 21; 8(1):14216.

-20C for 3 years in powder form

Synonym: PF-6465469; PF 6465469; PF6465469; PF-06465469; PF 06465469; PF06465469
IUPAC/Chemical Name: 3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3, 4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide
InChi Key: CGJVMKJGKFEHTL-HSZRJFAPSA-N
InChi Code: InChI=1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6, 8-9, 11-12, 14-15, 17-18, 23H, 1, 7, 10, 13, 16H2, 2-4H3, (H, 34, 39)(H2, 31, 32, 33)/t23-/m1/s1
SMILES Code: O=C(NC1=CC=C(C(C)C)C(C)=C1)C2=CC=CC(C3=NN([CH]4CN(C(C=C)=O)CCC4)C5=NC=NC(N)=C53)=C2