Alflutinib mesylate (Furmonertinib)

InvivoChem Cat #:V4747CAS #:2130958-55-1Purity >=98%

Description: Alflutinib mesylate (formerly also known as AST2818 mesylate), the mesylate salt form of Alflutinib, is a novel, potent and third generation EGFR inhibitor that targets both EGFR activating mutations and T790M, leading to inhibition of tumor growth.

References: J Thorac Oncol. 2017 Nov, 12(11): S2138.

Related CAS : 2130958-55-1 (mesylate); 1869057-83-9 (free base)

-20C for 3 years in powder form

Synonym: AST 2818, AST-2818 mesylate, AST2818 mesylate
IUPAC/Chemical Name: N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2, 2, 2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate
InChi Key: WDPGHXINXNBHAS-UHFFFAOYSA-N
InChi Code: 1S/C28H31F3N8O2.CH4O3S/c1-6-24(40)33-21-15-22(26(41-17-28(29, 30)31)36-25(21)38(4)14-13-37(2)3)35-27-32-12-11-20(34-27)19-16-39(5)23-10-8-7-9-18(19)23; 1-5(2, 3)4/h6-12, 15-16H, 1, 13-14, 17H2, 2-5H3, (H, 33, 40)(H, 32, 34, 35); 1H3, (H, 2, 3, 4)
SMILES Code: CN(C)CCN(C)c1nc(OCC(F)(F)F)c(Nc2nccc(n2)c3cn(C)c4ccccc34)cc1NC(=O)C=C.CS(=O)(=O)O