TAB1 cDNA

cDNA

TAB1 encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Human

602615

1515bp

1. Centrifuge at 7000rpm for 1 minute.; ; 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA.; ; Each tube contains approximately 10ug of lyophilized plasmid.

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV VTAP

ATGGCGGCGC AGAGGAGGAG CTTGCTGCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC CTGCCTCTCT GCCACCTCTC TGGGGTTGGC TCAGCCTCCA ACCGCAGCTA CTCTGCTGAT GGCAAGGGCA CTGAGAGCCA CCCGCCAGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC AACTGCTTCC TGTATGGGGT CTTCAACGGC TATGATGGCA ACCGAGTGAC CAACTTCGTG GCCCAGCGGC TGTCCGCAGA GCTCCTGCTG GGCCAGCTGA ATGCCGAGCA CGCCGAGGCC GATGTGCGGC GTGTGCTGCT GCAGGCCTTC GATGTGGTGG AGAGGAGCTT CCTGGAGTCC ATTGACGACG CCTTGGCTGA GAAGGCAAGC CTCCAGTCGC AATTGCCAGA GGGAGTCCCT CAGCACCAGC TGCCTCCTCA GTATCAGAAG ATCCTTGAGA GACTCAAGAC GTTAGAGAGG GAAATTTCGG GAGGGGCCAT GGCCGTTGTG GCGGTCCTTC TCAACAACAA GCTCTACGTC GCCAATGTCG GTACAAACCG TGCACTTTTA TGCAAATCGA CAGTGGATGG GTTGCAGGTG ACACAGCTGA ACGTGGACCA CACCACAGAG AACGAGGATG AGCTCTTCCG TCTTTCGCAG CTGGGCTTGG ATGCTGGAAA GATCAAGCAG GTGGGGATCA TCTGTGGGCA GGAGAGCACC CGGCGGATCG GGGATTACAA GGTTAAATAT GGCTACACGG ACATTGACCT TCTCAGCGCT GCCAAGTCCA AACCAATCAT CGCAGAGCCA GAAATCCATG GGGCACAGCC GCTGGATGGG GTGACGGGCT TCTTGGTGCT GATGTCGGAG GGGTTGTACA AGGCCCTAGA GGCAGCCCAT GGGCCTGGGC AGGCCAACCA GGAGATTGCT GCGATGATTG ACACTGAGTT TGCCAAGCAG ACCTCCCTGG ACGCAGTGGC CCAGGCCGTC GTGGACCGGG TGAAGCGCAT CCACAGCGAC ACCTTCGCCA GTGGTGGGGA GCGTGCCAGG TTCTGCCCCC GGCACGAGGA CATGACCCTG CTAGTGAGGA ACTTTGGCTA CCCGCTGGGC GAAATGAGCC AGCCCACACC GAGCCCAGCC CCAGCTGCAG GAGGACGAGT GTACCCTGTG TCTGTGCCAT ACTCCAGCGC CCAGAGCACC AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGAT GGTCAACGGG GCTCACAGTG CTTCCACCCT GGACGAAGCC ACCCCCACCC TCACCAACCA AAGCCCGACC TTAACCCTGC AGTCCACCAA CACGCACACG CAGAGCAGCA GCTCCAGCTC TGACGGAGGC CTCTTCCGCT CCCGGCCCGC CCACTCGCTC CCGCCTGGCG AGGACGGTCG TGTTGAGCCC TATGTGGACT TTGCTGAGTT TTACCGCCTC TGGAGCGTGG ACCATGGCGA GCAGAGCGTG GTGACAGCAC CGTAG