FSBP cDNA

cDNA

Fibrinogen silencer-binding protein, also known as FSBP, is interacts with X11alpha. X11alpha/FSBP complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains.

Human

616306

900bp

1. Centrifuge at 7000rpm for 1 minute.; ; 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA.; ; Each tube contains approximately 10ug of lyophilized plasmid.

MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA VNYNAIGVDRPPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP TKKVMEMIPQ ISSFCLVRDRNHIQSANLDE EAQAGTSSLQ VMLDHHPVAI TVEVKQEEDI KPPPPLVLNS QQSDTLEQREEHELVHVMER SLSPSLSSVD MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLKEEHQIILENQ KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL

ATGGTAGGAAAGGCTAGATCTTCCAATTTTACCTTATCCGAAAAGCTTGATTTGCTAAAGCTTGTGAAGCCATATGTGAAAATTCTCGAAGAACACACTAATAAACATTCAGTAATAGTAGAAAAGAATAGATGTTGGGATATCATAGCAGTTAACTATAATGCAATTGGAGTAGACCGCCCTCCTCGAACAGCACAGGGCCTACGCACCCTTTATAAAAGGCTCAAAGAATATGCCAAACAGGAGCTATTGCAGCAAAAAGAGACCCAATCAGATTTTAAAAGCAATATTTCTGAGCCAACCAAGAAAGTTATGGAGATGATTCCCCAGATTTCCAGTTTTTGCCTGGTAAGAGACAGGAACCACATACAAAGTGCAAACTTGGATGAGGAGGCACAGGCTGGTACCAGTTCACTACAGGTAATGTTGGATCACCATCCTGTTGCTATTACAGTGGAGGTGAAGCAAGAAGAAGACATTAAACCACCTCCTCCACTGGTTTTAAATTCTCAACAGAGTGATACTTTAGAGCAAAGAGAAGAACATGAATTAGTACATGTTATGGAAAGATCCTTGTCGCCTTCACTTTCCTCTGTTGATATGAGAATGACATCGTCTCCATCTTCTATTCCAAGGAGAGATGATTTTTTTCGGCATGAGAGTGGTGAACACTTTAGGTCACTATTAGGGTATGATCCTCAGATCCTGCAAATGTTGAAAGAGGAGCATCAGATAATTTTAGAAAATCAAAAAAATTTTGGATTGTATGTTCAGGAGAAGAGGGATGGATTGAAAAGAAGGCAGCAGCTAGAGGAAGAGCTACTAAGAGCAAAAATTGAAGTGGAGAAGCTGAAAGCAATTCGCTTACGGCATGATCTACCTGAATATAACAGTCTCTAA