Canine IFN-gamma ELISA Kit

Interferon gamma (IFN-I³), also known as type II interferon, is a member of the cytokine family and the only member of the type II class of interferons identified so far. IFN-I³ is produced by a number of cell types under inflammatory conditions, including dendritic epidermal/I³I´ T cells, keratinocytes, peripheral blood I³I´ T cells, mast cells, neurons, CD8+ T cells, macrophages, B cells, neutrophils, NK cells, CD4+ T cells, and testicular spermatids. Rat IFN-I³ shares approximately 87% and 39% amino acid sequence identity with mouse IFN-I³ and human IFN-I³, respectively. Consistent with their degrees of shared homology, rat IFN-I³ is active on mouse cells but not on human cells. Biologically active IFN-I³ consists of a noncovalently linked homodimer which binds to transmembrane IFN-I³ RI (alpha subunit) coupled with transmembrane IFN-I³ RII (beta subunit) to form a functional receptor complex of two I+/- and two beta subunits. IFN-I³ is essential to promote anti-viral, anti-proliferative, and immunoregulatory activities. On many cell types, IFN-I³ induces the production of cytokines and upregulates the expression of various membrane proteins including class I and II MHC antigens, Fc receptors, leukocyte adhesion molecules, and B7 family antigens. IFN-I³ also plays a key role in the pathogenesis of certain inflammatory diseases such as autoimmunity and atherosclerosis.

31.2-2000pg/mL

Store at 2 - 8 C. Keep reconstituted standard and detection Ab at -20 C