Human CCL24/Eotaxin-2 ELISA Kit

Eotaxin-2, also known as CCL24, MPIF-2, or Ckbeta-6, is a small cytokine belonging to the CC chemokine family. Eotaxin-2 mRNA is expressed in activated T lymphocytes, GM-CSF treated macrophages, and dermal fibroblasts. Mature Eotaxin-2 is a 93 amino acid (aa) glycoprotein exhibiting relatively low aa identity with Eotaxin. Eotaxin-2 selectively recruits and activates eosinophils and basophils both in vitro and in vivo. Eotaxin-2 primarily binds to the G-protein-coupled receptor CCR3 expressed on eosinophils, basophils, subpopulations of Th2 lymphocytes, and keratinocytes to initiate a series of biological processes including actin polymerization, a transient rise in cytosolic calcium concentration, and release of reactive oxygen species. However, CCR3 is also a ligand for other chemokines such as Eotaxin, MCP-2, MCP-3, MCP-4, MIP-1I´, and RANTES. Eotaxin-2 has been implicated in certain pathological conditions linked to allergic reactions and parasitic infections.

78-5, 000pg/mL

Store at 2 - 8 C. Keep reconstituted standard and detection Ab at -20 C