Human IL-10 ELISA Kit

Interleukin 10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), family of interleukin 1-theta (FIL1 theta), Interleukin-1 HY2 (IL-1HY2), Interleukin-1 theta (IL-1 theta) Interleukin-38 (IL-38), is a member of the IL-10 family. Mature human IL-10 shares 74% sequence identity with rat IL-10. IL-10 is secreted by activated hematopoietic cells, hepatic stellate cells, keratinocytes, and placental cytotrophoblasts. IL-10 exists in a homodimer and transduces its signals by binding to a heteromeric receptor complex composed of the type II cytokine receptor subunits IL-10 RI+/-/IL-10R1 and IL-10 Rbeta/IL-10R2. The IL-10 dimer binds to two IL 10 RI+/- chains, and thus recruits two IL-10 Rbeta chains and activates a signaling cascade involving JAK1, TYK2, and STAT3. IL-10 is a pleiotropic cytokine that plays positive and negative roles in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. It is reported that IL-10 is critical to the controlling of viral infections as well as allergic and autoimmune inflammation. Polymorphisms of IL-10 gene have been associated with the development of autoimmunity, viral infection, and cancer.

7.8-500pg/mL

Store at 2 - 8 C