Human IL-15 ELISA Kit

IL -15 is a glycoprotein encoded by IL-15 gene in human. Human IL-15 is synthesized as a 162 amino acid (aa) precursor protein composed of a 48 aa signal peptide and a 114 aa mature fragment. In humans, an alternatively spliced form has also been identified. Human IL-15 shares approximately 73% aa sequence identity with mouse IL-15 and is active on mouse cells. The IL-15 receptor complex consists of three molecules: an IL-15 specific I+/--chain, a beta-chain and I³-chain that is shared by the receptor complex for IL-2. The I+/--chain is a 237 aa protein and binds IL-15 with high affinity. It shows 54% aa sequence identity with mouse IL-15 RI+/-. Although the IL-15 receptor is composed of 3 chains, only the betaI³ dimer is required for IL-15 signaling. IL-15 plays various roles in immunoregulation. It stimulates the growth of natural killer cells, activated peripheral blood T lymphocytes, tumor infiltrating lymphocytes (TILs), and B cells. In addition, IL-15 also is a chemoattractant for human blood T lymphocytes and to induce both lymphokine-activated killer (LAK) activity in NK cells and the generation of cytolytic effector cells.

15.6--1000pg/mL

serum, plasma or cell culture supernatant

Store at 2 - 8 C