Human IL-24 ELISA Kit

Interleukin 24 (IL-24), also known as mda-7 (melanoma differentiation associated gene 7) or suppression of tumorigenicity 16 protein, is a member of the IL-10 family. Human IL-24 is synthesized as a 206 amino acid (aa) precursor protein containing a signal sequence and an 18 kDa mature segment. There are three potential N-linked glycosylation sites in IL-24, and glycosylation is essential to its activity. Mature human IL-24 shares 69% aa sequence identity with mouse and rat counterparts and shows species cross-reactivity in rodent systems. IL-24 is expressed in a variety of cells including B cells, CD4+ T cells, NK cells, lymph node dendritic cells, monocytes, melanocytes, and melanoma cells. IL-24 interacts with two heterodimeric receptors: IL-20RI+/-/IL-20Rbeta and IL-22R1/IL-20Rbeta to transduce its signals in target cells. IL-24 has exhibited multiple functions in inducing production of proinflammatory cytokines such as IFN-I³, IL-1beta, IL-12 and TNFI+/-, regulating cell survival and proliferation by activating the transcription factors STAT1 and STAT3 as well as anti-angiogenic activity.

62.5--4000pg/mL

Store at 2 - 8 C. Keep reconstituted standard and detection Ab at -20 C