Human Thrombomodulin/BDCA-3 ELISA Kit

Human thrombomodulin, also known as Fetomodulin, BDCA-3 and CD141, is a transmembrane protein encoded by the THBD gene in humans. Thrombomodulin is composed of an N-terminal C-type lectin domain, six contiguous epidermal growth factor (EGF)-like domains, a highly glycosylated serine/threonine-rich domain, a transmembrane segment, and a short C-terminal cytoplasmic tail. Thrombomodulin is expressed primarily by vascular endothelial cells. Thrombomodulin plays an important role in the anti-coagulation and fibrinolysis system. When the coagulation cascade is activated, prothrombin is converted to thrombin by coagulation factors Va and VIIIa, ultimately leading to fibrin clot formation. Thrombin binds to thrombomodulin and then activates protein C to degrade coagulation factors Va and VIIIa, thereby reducing the amount of thrombin generated and inhibiting coagulation. Thrombomodulin-thrombin complex also activates thrombin-activatable fibrinolysis inhibitor (TAFI), creating a carboxypeptidase that inhibits fibrinolysis. It has been shown that patients suffering from cardiovascular diseases, such as acute coronary syndrome, pulmonary thromboembolism, and severe hemorrhage, have increased circulating thrombomodulin concentrations.

62.5--4000pg/mL

Store at 2 - 8 C