Human Phospho-ATM ( S1981 ) ELISA Kit Intracellular

Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase belonging to the superfamily of Phosphatidylinositol 3-kinase-related kinases (PIKKs). It is a 3056 amino acid (aa) protein characristic of HEAT repeat domain, the FRAP-ATM-TRRAP (FAT) domain, the kinase domain (KD), the PIKK-regulatory domain (PRD) and the FAT-C-terminal (FATC) domain. ATM plays an important role in regulation of DNA damage and repair by phosphorylating several key proteins that initiate activation of the DNA damage checkpoint. ATM is activated through auto- or trans- phosphorylation of Ser-1981 in response to DNA damage, particularly induction of DNA double-strand breaks (DSBs). This phosphorylation provokes dissociation of ATM dimers, which is followed by the release of active ATM monomers. Ataxia telangiectasia (AT) is a rare human disease characterized by cerebellar degeneration, extreme cellular sensitivity to radiation and a predisposition to cancer. All AT patients contain mutations in the ATM gene. ATM defects have been associated with breast cancer, Mantle cell lymphoma, T-ALL, atypical B cell chronic lymphocytic leukemia, and T-PLL.

6.25--200ng/ml

Store at 2 - 8 C