Human Sm antibody IgG ELISA Kit

Smith (Sm) antigen is a non-histone nuclear protein composed of several polypeptides of differing molecular weights. Anti-Sm autoantibodies were described originally as precipitating autoantibodies in sera of patients with Systemic Lupus Erythematosus. Approximately 99% of individuals with anti-Sm antibodies have the disease, but only 20% of people with SLE have the antibodies. Sm antibodies are associated with central nervous system involvement, kidney disease, lung fibrosis and pericarditis in SLE, but they are not associated with disease activity. Molecular and epidemiological studies suggest that anti-Sm antibodies may be induced by molecular mimicry because the protein shows some similarity to Epstein-Barr virus proteins.

99%

10 uL Serum or Plasma

75 min

Human ELISA Kits