Human CD95 / APO-1 / TNFRSF6 / FAS ELISA Kit

CD95, also known as APO-1, Fas and TNFRSF6, is a cell surface glycoprotein expressed by a substantial minority of resting T and B cells, and by about 5% of resting NK cells. CD95 is the receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases, mediating apoptosis. CD95 is strongly upregulated on activated T, B and NK cells.Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A).

4.7-300pg/ml

100 uL final volume, dilution factor varies on samples.

Human ELISA Kits