Interleukin-13 Mouse Recombinant ( IL 13 Mouse )

Interleukin-13 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 111 amino acids and having a molecular mass of 12.3 kDa. The IL-13 is purified by proprietary chromatographic techniques.

The vial contains antibody in PBS, pH 7.4, containing 0.1% of sodium azide as preservative.

The protein (1mg/ml) was lyophilized in PBS, pH 7.2 and 5% trehalose.

IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

Sterile Filtered White lyophilized (freeze-dried) powder.

The ED50 range=4 ng/ml, corresponding to a specific activity of 250, 000IU/mg as determined by the dose dependent proliferation of TF-1 cells.

Immunology