Rabbit antibody to Synaptotagmin 2

Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
SUBUNIT: Homotetramer. Interacts with stonin 2.
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules.

IHC, WB. A dilution of 1 : 1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Geppert M, et al. J. Biol. Chem. 266:13548-13552(1991).

A synthetic peptide from rat Synaptotagmin2 conjugated to blue carrier protein was used as the antigen.

http://ca.expasy.org/uniprot/P29101
http://ca.expasy.org/uniprot/P46097

Polyclonal

Lyophilised