Rabbit antibody to ATP13A4 (1120-1170)

Involvement in disease: Note=A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv3(q25; q29). The inversion produces a disruption of the protein.
Subcellular location: Membrane; Multi-pass membrane protein. Lysosome
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen.

IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Kwasnicka-Crawford D.A, et al. Genomics 86:182-194(2005)

A synthetic peptide from aa region 1120-1170 of human ATP13A4 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/Q4VNC1

Polyclonal

Lyophilised