Rabbit antibody to HCN1

FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli.
SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN2. Interacts with KCNE2.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

IHC, WB. A dilution of 1 : 500 to 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Schmutz J, et al. Nature 431:268-274(2004).

A synthetic peptide from human HCN1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and marmoset.

http://ca.expasy.org/uniprot/O60741
http://www.uniprot.org/uniprot/O88704
http://www.uniprot.org/uniprot/F7IND0

Polyclonal

Lyophilised