Rabbit antibody to Synapsin 1 (595-645)

May act as an anchoring protein by linking the vesicle phospholipid layer and the cytoskeleton in neuronal presynaptic terminals; may play a role in neurotransmitter release.
FUNCTION: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
SUBCELLULAR LOCATION: Cell junction, synapse. Golgi apparatus.

IHC, WB. A dilution of 1 : 2000 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Ross M.T, et al. Nature 434:325-337(2005)
2. Matsuoka S, et al. Science 316:1160-1166(2007)

A synthetic peptide from aa region 595-645of human Synapsin 1 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/P17600
http://www.uniprot.org/uniprot/P09951
http://www.uniprot.org/uniprot/O88935

Polyclonal

Lyophilised