Rabbit antibody to SLC30A5

FUNCTION: Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
SUBCELLULAR LOCATION: Golgi apparatus a€C trans-Golgi network membrane; Multi-pass membrane protein. INDUCTION: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.
TISSUE SPECIFICITY: Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells

IHC, WB. A dilution of 1: 2000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Kambe T, et al. J. Biol. Chem. 277:19049-19055(2002)

A synthetic peptide from internal cytoplasmic region of human Zinc transporter 5 (SLC30A5) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

http://www.uniprot.org/uniprot/Q8TAD4
http://www.uniprot.org/uniprot/Q8R4H9
http://www.uniprot.org/uniprot/D3ZY54

Polyclonal

Lyophilised