Rabbit antibody to SLC36A1

FUNCTION: Neutral amino acid/proton symporter. Probably involved in the efflux of lysosomal proteolysis products such as L-proline, L-alanine and glycine from the cell. May play a role in specifying sites for exocytosis in neurons.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note: In neurons, colocalizes with the exocyst complex in the axonal processes.
TISSUE SPECIFICITY: Widely expressed and predominantly expressed in brain. Within the brain, expression restricted to neurons and not detected in glial cells. Abundant in regions rich in neurons using glutamate and GABA such as Purkinje cells in the cerebellum and pyramidal cells in the hippocampus.

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Chen Z, et al. J. Physiol. (Lond.) 546:349-361(2003)
2. Bermingham J.R. Jr, et al. Mamm. Genome 15:114-125(2004)

A synthetic peptide from aa region 5-50 of mouse SLC36A1 conjugated to an immunogenic carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/Q7Z2H8
http://www.uniprot.org/uniprot/Q8K4D3
http://www.uniprot.org/uniprot/Q924A5

Polyclonal

Lyophilised