Rabbit antibody to VAMP A/B (50-100)

FUNCTION: May play a role in vesicle trafficking.
SUBUNIT: Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein. Intracytoplasmic membrane; Single-pass type IV membrane protein. Note: Present in the plasma membrane and in intracellular vesicles.
TISSUE SPECIFICITY: Ubiquitous. Isoform 1 predominates.
DISEASE: Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 (ALS8). ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
DISEASE: Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy; also called late-onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late- adult-onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.

IHC, WB. A dilution of 1 : 2000 to 1 : 3000 is recommended for WB and 1:1000 to 1:2000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Nishimura Y, et al. Biochem. Biophys. Res. Commun. 254:21-26(1999).

A synthetic peptide from aa region 50-100 of human VAMPB conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many species including human, rat, mouse, zebra fish, bovine, xenopus and chicken.

http://ca.expasy.org/uniprot/O95292
http://ca.expasy.org/uniprot/Q9Z269
http://ca.expasy.org/uniprot/Q9QY76

Polyclonal

Lyophilised