Rabbit antibody to GABA(A) R beta-3

FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Defects in GABRB3 are associated with chronic insomnia, a condition of inability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Defects in GABRB3 are the cause of childhood absence epilepsy type 5 (ECA5).
SUBCELLULAR LOCATION: Cell junction a€C synapse a€C postsynaptic cell membrane; Multi-pass membrane

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Wagstaff J, et al. Genomics 11:1071-1078(1991)
2. Kirkness E.F, et al. J. Biol. Chem. 268:4420-4428(1993)
3. Buhr A, et al. Hum. Genet. 111:154-160(2002)

A synthetic peptide from aa region 300-400 of human GABA(A) receptor subunit beta-3 conjugated to an immunogenic carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/P28472
http://www.uniprot.org/uniprot/P63079
http://www.uniprot.org/uniprot/P63080

Polyclonal

Lyophilised