Rabbit antibody to SLC5A1

FUNCTION: Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Tissue specificity: Expressed mainly in intestine and kidney.
Involvement in disease: Defects in SLC5A1 are the cause of congenital glucose/galactose malabsorption (GGM). GGM is an intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.

IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Hediger M.A, et al. Proc. Natl. Acad. Sci. U.S.A. 86:5748-5752(1989)
2. Turk E, et al. J. Biol. Chem. 271:1925-1934(1996)
3. Turk E, et al. Nature 350:354-356(1991)
4. Lam J.T, et al. Biochim. Biophys. Acta 1453:297-303(1999)
5. Kasahara M, et al. Biochim. Biophys. Acta 1536:141-147(2001)

A synthetic peptide from extracellular domain of human high affinity sodium-glucose cotransporter (SLC5A1) conjugated to an immunogenic carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/P13866

Polyclonal

Lyophilised