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Rabbit antibody to IP3R 1 (700-750)

Rabbit antibody to IP3R 1 (700-750)

ArtNr	OST00428W
Hersteller	Osenses
Menge	100ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Inositol 1,4,5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R1, InsP3R1, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor, INSP3R1
Similar products	4, Inositol 1, INSP3R1, IP3R1, Type 1 inositol 1, 5-trisphosphate receptor, 5-trisphosphate receptor type 1, InsP3R1, IP3 receptor isoform 1, Type 1 InsP3 receptor
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Also known	Inositol 1, 4, 5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R1, InsP3R1, Type 1 inositol 1, 4, 5-trisphosphate receptor, Type 1 InsP3 receptor, INSP3R1
Target	FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed.
Spcs X-react.	Human. Other species not yet tested but expected to work in rat and mouse.
Applications info	IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Shipping	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Yamada N, et al. Biochem. J. 302:781-790(1994)
Limitation	For research use only
Immunogen	A synthetic peptide from aa region 700-750 of human IP3R1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Conjugate	Unconjugated antibody
Accession	http://www.uniprot.org/uniprot/Q14573 http://www.uniprot.org/uniprot/P29994 http://www.uniprot.org/uniprot/P70227
Purity	Whole serum
Clonality	Polyclonal
Specificity	Specific for INSP3R1.
Format	Lyophilised
Reconstitution	Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100ul

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