Rabbit antibody to Syntaxin16

FUNCTION: SNARE involved in a vesicular transport step within the Golgi stack.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein.
SUBCELLULAR LOCATION: Isoform C: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
DISEASE: Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B.

IHC, WB. A dilution of 1 : 500 to 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Carninci P, et al. Science 309:1559-1563(2005).

A synthetic peptide from mouse Syntaxin16 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in chicken, orangutan and pig.

http://ca.expasy.org/uniprot/Q8BVI5

Polyclonal

Lyophilised