Rabbit antibody to SLC1A3

FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6). EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.

IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Schulte S, et al. Eur. J. Biochem. 233:947-953(1995)

A synthetic peptide from c-terminal region of mouse EAAT1 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat.

http://www.uniprot.org/uniprot/P56564
http://www.uniprot.org/uniprot/P24942

Polyclonal

Lyophilised