Rabbit antibody to KCNJ12

FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Tissue specificity: Highest level in cerebellum. Moderately found in kidney, forebrain and skeletal muscle. Not detected in uterus, liver and pancreas.
Subcellular location: Membrane, Multi-pass membrane protein.

IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Koyama H, et al. FEBS Lett. 341:303-307(1994)
2. Leonoudakis D, et al. J. Biol. Chem. 279:19051-19063(2004)

A synthetic peptide from the cytoplasmic domain of rat KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse.

http://www.uniprot.org/uniprot/P52188
http://www.uniprot.org/uniprot/P52187

Polyclonal

Lyophilised