Rabbit antibody to VAMP-1

FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
SUBUNIT: Interacts with VAPA and VAPB.
SUBCELLULAR LOCATION: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
SUBCELLULAR LOCATION: Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Note: Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
SUBCELLULAR LOCATION: Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
TISSUE SPECIFICITY: Expressed in brain and spleen (at protein level). Isoform 1 expressed at very high level in brain. Even higher level found in spinal cord. Isoform 3 expressed in kidney, spleen and liver. Isoforms 2 and 3 expressed in osteoblasts of trabecular bone. Also expressed in heart.

IHC, WB. A working concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user.

12 months after reconstitution

1. Elferink L.A, et al. J. Biol. Chem. 264:11061-11064(1989).
2. Mandic R, et al. Gene 199:173-179(1997).
3. Prele C.M, et al. Exp. Cell Res. 282:24-34(2003).

A synthetic peptide from aa region 2-35 of mouse VAMP-1 conjugated to an immunogenic carrier protein was used as the antigen.

http://kr.expasy.org/uniprot/Q63666
http://kr.expasy.org/uniprot/Q62442

Polyclonal

Lyophilised