Rabbit antibody to SLC11A2

FUNCTION: Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Defects in SLC11A2 are a cause of hypochromic microcytic anemia (HCMA)
SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein
TISSUE SPECIFICITY: Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.

IHC, WB. A dilution of 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Mackenzie B, et al. Biochem. J. 403:59-69(2007)

A synthetic peptide from mouse SLC11A2 conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/P49281
http://www.uniprot.org/uniprot/O54902
http://www.uniprot.org/uniprot/P49282

Polyclonal

Lyophilised