BACE2 Antibody (C-term) Blocking peptide

Peptides; Blocking Peptides

Cerebral deposition of amyloid beta peptide is an earlyand critical feature of Alzheimer's disease and a frequentcomplication of Down syndrome. Amyloid beta peptide is generated byproteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This genelocalizes to the 'Down critical region' of chromosome 21. Theencoded protein, a member of the peptidase A1 protein family, is atype I integral membrane glycoprotein and aspartic protease. Threetranscript variants encoding different isoforms have been describedfor this gene.

Synthetic peptide

Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, AEPLC, ALP56, ASP21