Bio Background |
SFRS3 is a member of theserine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factorscontains an RNA recognition motif (RRM) for binding RNA and an RSdomain for binding other proteins. The RS domain is rich in serineand arginine residues and facilitates interaction between differentSR splicing factors. In addition to being critical for mRNAsplicing, the SR proteins have also been shown to be involved inmRNA export from the nucleus and in translation. Two transcriptvariants, one protein-coding and the other non-coding, have beenfound for this gene. |
Bio References |
Verma, D., et al. J. Virol. 84(22):11781-11789(2010)Anko, M.L., et al. Nat. Struct. Mol. Biol. 17(8):962-970(2010)Escudero-Paunetto, L., et al. Virology 401(2):155-164(2010)Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)Fingert, J.H., et al. Mol. Vis. 16, 596-601 (2010) : |