MASP1 Antibody (Center) Blocking Peptide

This gene encodes a serine protease that functions as acomponent of the lectin pathway of complement activation. Thecomplement pathway plays an essential role in the innate andadaptive immune response. The encoded protein is synthesized as azymogen and is activated when it complexes with the pathogenrecognition molecules of lectin pathway, the mannose-binding lectinand the ficolins. This protein is not directly involved incomplement activation but may play a role as an amplifier ofcomplement activation by cleaving complement C2 or by activatinganother complement serine protease, MASP-2. The encoded protein isalso able to cleave fibrinogen and factor XIII and may may beinvolved in coagulation. A splice variant of this gene which lacksthe serine protease domain functions as an inhibitor of thecomplement pathway. Alternate splicing results in multipletranscript variants.

5648

Synthetic peptide