SDHB Blocking Peptide (C-term)

Peptides; Blocking Peptides

Complex II of the respiratory chain, which is specificallyinvolved in the oxidation of succinate, carries electrons from FADHto CoQ. The complex is composed of four nuclear-encoded subunitsand is localized in the mitochondrial inner membrane. Theiron-sulfur subunit is highly conserved and contains threecysteine-rich clusters which may comprise the iron-sulfur centersof the enzyme. Sporadic and familial mutations in this gene resultin paragangliomas and pheochromocytoma, and support a link betweenmitochondrial dysfunction and tumorigenesis.

Synthetic peptide